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Phone: 856-599-8059 Email: info@coriell.com

Address: 403 Haddon Avenue | Camden, NJ 08103

Green Circle

Here’s the solution...

GeneDose is a Medication Risk Management Tool—
Empowering Physicians Through Simplified Genomics

With this simple non-invasive test, practitioners are provided with a report indicating
which drugs will work, which will be dangerous, and in many cases, what dosage will
be most appropriate— all on an individual, specific patient basis.

The Process... 4 Simple Steps to better health

Step 1

Order Your Complete
GeneDose Kit Today

Step 2

Complete test requisition
and consent form

Step 3

Collect sample
(buccal swab)

Step 4

Return sample to lab
(pre-paid envelope)

Get Your Kit Today!

Clinically Relevant, Medically Actionable

GeneDose™ leverages the scientific data and expertise of the 62-year-old Coriell Institute for Medical Research. Backed by CLIA-licensed laboratories and genotyping assays, GeneDose™ Genetic Response Report provides physicians with recommendations that they can understand changes in doses, suggested medications by therapeutic class, and warnings. Gone are the days of trying to translate genotypes into clinically useful information; no more trial and error medication management before seeing patient improvement.

GeneDoseTM LIVE

GeneDose™ LIVE merges more than a dozen precision prescribing decision vectors and builds on the genetic insight the GeneDose™ Genetic Response Report provides. In real-time, the visual report relays a quick summarization of which drugs present the highest degree of risk and provides physicians with a tool to virtually modify and assess the treatment plan and find the scenario that presents the least amount of risk, while still accomplishing the intended therapy.

Pharmacokinetics, the understanding of what the body does to a drug, is impacted by genetics. GeneDose™ screens genes that impact the transport of drugs into the cell; transform prodrugs into their active forms; are responsible for detoxifying and excreting the drug; and are associated with a change in response to treatment.

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GeneDoseTM Pharmacogenomic test and report

Genetic variation influences the way drugs are processed and utilized by the body. Pharmacogenomics is the science that explores the effects of specific genetic variants. GeneDose™ tests the clinically relevant pharmacogenomic genes in a single, comprehensive test and the GeneDose™ Genetic Response Report provides the detailed pharmacogenomic results and the correlative clinical effects for individuals. This insightful tool supports the physician in making scientifically reinforced treatment decisions.

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For Physicians and Healthcare providers

GeneDose™ Genetic Response Report and GeneDose™ LIVE provides easy to understand recommendations to use directly while making medical decisions—concise and understandable without a need for a genetics background.

GeneDose™ helps tune medication regimens. GeneDose™ simplifies the complex issue of personalized medication management for drugs that are affected by genetic variations.

Advantages of GeneDoseTM
  • Displays drug-specific guidance and interpretation.
  • Reports medications, listed by drug class, with icons that call attention to the severity of the interpretation.
  • Delivers across existing, easy-to-use computer systems.
  • Reimbursable by most insurance providers.
  • Decrease the risk of unanticipated Adverse Drug Reactions.
  • Reduce repeat visits for dosing and drug side effects.
  • Increase patient compliance.
  • GeneDose™ LIVE – multivariable advisory tool that takes into account genetics, demographics, lifestyles, and medical conditions.
Healthcare Providers
Computer
For Payers and ACOs

GeneDose™ Genetic Response Report and GeneDose™ LIVE help you meet the triple aim of improving population health, patient experience, and reducing the per capita cost of healthcare. Imagine the benefit of providing the right antiplatelet agent (Plavix® doesn’t work for >27% of the population)—it could help ensure that your patient avoids a second heart attack. Imagine selecting the appropriate antidepressant at the first patient visit—not waiting 6 to 8 weeks for efficacy results. GeneDose™ can help tailor medication regimens to the patient, increasing patient compliance, and reducing repeat visits for dosage adjustments and treatment for adverse reactions.

Understanding Pharmacogenomics

An in-depth understanding of the medication of interest along with the patient’s genetics is paramount to proper personalized medication management. It is not enough to know the metabolizer status of a patient.

A patient can be any of four metabolizer statuses for a particular metabolic enzyme (tested by screening specific places within the genome): an extensive metabolizer (normal metabolic activity); an intermediate or poor metabolizer (reduced or lacking activity); or an ultrarapid metabolizer (increased metabolic activity).

White Paper

Medications fall into two main categories when considering their metabolism: Active drug (that the body will subsequently try to excrete), and prodrug (that the body tries to turn into the active drug).

GeneDose™ Clinical recommendations are presented based on the patient’s genotype (genetics for a particular metabolic enzyme), the correlative metabolic activity for the enzyme of interest, and solid scientific and clinical outcome information on how a particular drug is metabolized by a patient with the same enzyme activity and genotype.

Genetics also affects the transport of drugs across the cell membrane. GeneDose™ screens hepatic intramembrane transporters—enzymes that must be intact for pharmacotherapeutic success of specific medications. GeneDose™ provides information on these medications, and alternative medications in the case where a patient can not correctly metabolize a drug because of the functional state of the transporter.

Therapeutic Classes Include:
  • Pain management
  • Cardiology
  • Gastroenterology
  • Neurology
  • Psychiatry
  • Anesthesiology
  • Endocrinology
  • Infectious diseases
  • Oncology
  • Rheumatology
Genes Tested:
  • ATM
  • CYP3A4
  • Factor 5
  • LDLR
  • TPMT
  • CYP2C19
  • CYP3A5
  • HLA-B
  • MTHFR
  • VKORC1
  • CYP2C9
  • CYP4F2
  • IL28B
  • SLCO1B1
  • CYP2D6
  • Factor II
  • ITPA
  • STK11

Want to Get Started?


Request Your Kit & Get on Track for Better Health!